GPCR networks

GPCR Interaction Network

Instructions About us

GPCR networks

HetNet
NonHetNet
RTK

Search protomer by name

Show all families Protomer families

About us

This web site was developed and designed by:

Ismel Brito Rodriguez,
Dasiel Oscar Borroto Escuela, and
Kjell Fuxe.

We would like to thank Michael Di Palma and Marina Mirchandani Duque for their support in bibliographic reference gathering.

If you encounter any difficulties as you use it or have any comments, please send us your feedback to Dasiel.Borroto-Escuela (at) ki (dot) se.

Instructions

This web site has been designed to visualize GPCR interaction networks. We distinguish between three types of interaction networks: HetNet, NonHetNet, and RTK. In the former, each receptor is a network node and every line between two receptors means that these two connected receptors interact according to consulted literature. In the NonHetNet network, every dotted line indicates that the two connected receptors do not interact. The RTK network shows interactions specific to receptor tyrosine kinases (RTKs), highlighting their unique pathways and connections. The size of each node in the network is determined by the number of links it has. On the site, you can visualize one of these three networks by selecting the desired network from the dropdown menu that appears in the top-left panel, as shown below.

netOptions

You might also be interested in seeing the interaction and non-interactions of a specific receptor (let's call it the target receptor). We provide you two ways to achieve this.

You might use the search input box that appears in the top-left panel. This is an autocomplete input box so you don't need to type the whole receptor name to find the target receptor. It is worth mentioning that we use UniProt receptor names in the search. Please visit Uniprot site to find out the proper receptor name.

searchBox

Alternatively, if you see the target receptor in the network, you can click on it.

In both cases, a new subnetwork is drawn in which the target receptor and its interactions/non-interactions are shown.

The site also contains three other panels. In the bottom-left panel we show the map between receptor families and network node colours. In the bottom-right corner we provide some topological properties of the network being shown.

The top-right panel is not always visible. It only provides information about a subnetwork for a given target receptor. For every receptor in the subnetwork we enlist the bibliographic references that claim the fact that it does/doesn't interact with the target receptor.

referenceList

For instance, the image above shows the reference list in the HetNet subnetwork for HER2 receptor.

Additionally, the URLs are shareable. After selecting a network and a receptor, you can copy the URL and share it with others. This allows them to view the same information and network configuration as you.

Network topology